Endocrine Abstracts

Aims: To assess the incidence of Ipilimumab associated hypophysitis and its common presentations.Methods: All patients who developed Ipilimumab induced hypophysitis following treatment for Malignant melanoma at a large tertiary care centre in West Midlands, United Kingdom from 2012 to 2014 were included in the study. Patients with known pituitary disease prior to treatment and/or received other systemic immunotherapy following Ipilimumab treatment were e...

Aim: To estimate the prevalence and clinical significance of hyponatraemia in patients with lung cancer.Methods: The data were obtained from Hospital Registry. The serum sodium (SNa) on diagnosis was used for statistical comparisons. Normonatraemia is defined as SNa 135–144 mmol/l, hyponatraemia <135 mmol/l, and hypernatraemia >145 mmol/l. The data was analysed for small cell (SCLC), non-small cell (NSCLC) and unknown group where histologica...

An 82-year-old man presented with weight loss and lethargy. Thyroid function tests showed a fT4 7.6 pmol/l and TSH 0.08 mU/l. Short synacthen test confirmed hypoadrenalism with baseline cortisol of 34 nmol/l and 30 min sample 156 nmol/l. He had low gonadotrphin levels and Prolactin was 551 μ/l. He was commenced on hydrocortisone and levothyroxine treatment with symptomatic improvement. An urgent CT scan revealed multiple enlarged lymph nodes above and below the diaphragm ...